Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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4,441 – 4,455 of 5,522 results

4,441

Medchemexpress LLC N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide | 162558-52-3 | 99.8% | 200 MG

MQAE is a chloride ion (Cl-) fluorescent probe designed for measuring chloride concentrations. Its fluorescence intensity decreases proportionally as chloride ion levels increase, making it suitable for various detection methods like confocal microscopy and flow cytometry (Ex/Em=350/460 nm). It exhibits high cell permeability and is intended for research use only.

Suitable for measuring chloride concentrations
Fluorescence intensity decreases with increasing chloride ions
High cell permeability
Compatible with confocal microscopy and flow cytometry

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4,442

Medchemexpress LLC Racemic equol | 94105-90-5 | MFCD00016662 | 99.6% | 242.27 g·mol⁻¹ | C15H14O3 | 200 MG

Racemic equol is the racemate of equol, a nonsteroidal estrogen receptor ligand and a metabolite of the soy isoflavones daidzin and daidzein. It is commonly used in research on estrogen receptor pharmacology and isoflavone metabolism, with reported EC50 values of 200 nM for ERα and 74 nM for ERβ.

Racemic mixture of equol suitable for receptor biology studies.
Shows EC50s of 200 nM (ERα) and 74 nM (ERβ).
Molecular weight 242.27 g·mol⁻¹ and formula C15H14O3.
High purity (≈99.6%) for consistent experimental results.
Solid powder form, stable when stored at low temperatures.
Available in multiple pack sizes from milligram to gram quantities.

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4,443

Medchemexpress LLC Amg-337 | 1173699-31-4 | 99.4% | 463.46 | 200 MG

AMG-337 is a potent, orally active, and selective MET kinase inhibitor. It effectively inhibits the phosphorylation of MET and its downstream effectors in MET-amplified cancer cell lines, leading to the inhibition of MET-dependent cell proliferation and the induction of apoptosis. This compound has demonstrated activity in both in vitro and in vivo studies, including various tumor xenograft models.

Potent and selective MET kinase inhibitor
Inhibits MET-dependent cell proliferation
Induces apoptosis in cancer cell lines
Effective in various tumor xenograft models

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4,444

Medchemexpress LLC Infigratinib | 872511-34-7 | 99.8% | 560.48 | 200 MG

Infigratinib, also known as BGJ-398 or NVP-BGJ398, is a potent inhibitor of the Fibroblast Growth Factor Receptor (FGFR) family. It targets FGFR1, FGFR2, FGFR3, and FGFR4 with high efficacy, making it suitable for various research applications.

Potent inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4
Inhibits proliferation of FGFR-dependent BaF3 cells
Effective against FGFR2-mutant endometrial cancer cells
Extensively studied in clinical trials for multiple cancers and conditions

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4,445

Apexbio Technology LLC Cyclophosphamide 50-18-0 200mg

Cyclophosphamide is a nitrogen mustard alkylating prodrug activated via hepatic enzymes to its active metabolites These metabolites alkylate DNA primarily at guanine residues resulting in DNA cross-linking strand breaks and mutations consequently triggering cytotoxic effects Cyclophosphamide exhibits cytotoxicity in vitro with an IC50 of 37 6 M in mouse embryo BALB/c 3T3 cells and an IC50 of 8 79 M against human HL60 cells It impacts immune regulation by decreasing regulatory T cell counts and suppressive marker expression (FoxP3 GITR) facilitating immune response modulation Commonly applied in cancer and immunological research cyclophosphamide is also employed in genotoxicity assays due to its capacity to induce chromosomal aberrations and mutations

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4,446

Apexbio Technology LLC PCI-24781 (CRA-024781) 783355-60-2 200mg

PCI-24781 (CRA-024781 CAS 783355-60-2) is a histone deacetylase (HDAC) inhibitor targeting HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 and HDAC10 with reported Ki values of 7 19 8 2 17 280 and 24 nM respectively HDAC enzymes catalyze the removal of acetyl groups from lysine residues on histone proteins thereby regulating chromatin structure and gene expression PCI-24781 induces dose-dependent hyperacetylation of histones and tubulin in human cancer cells (HCT116 DLD-1) leading to apoptosis via p21 upregulation PARP cleavage and H2AX accumulation PCI-24781 demonstrates antitumor activity against multiple tumor cell lines and in xenograft models highlighting its utility for oncology research

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4,447

Apexbio Technology LLC Sivelestat (ONO-5046) 127373-66-4 200mg

Sivelestat (ONO-5046) is a selective inhibitor of neutrophil elastase with an IC50 value of 44 nM Neutrophil elastase a serine protease secreted by activated neutrophils can degrade extracellular matrix components and contribute to tissue injury in inflammatory diseases such as rheumatoid arthritis emphysema acute respiratory distress syndrome (ARDS) and septic shock Sivelestat inhibits human neutrophil elastase in a competitive manner and similarly reduces the activity of leukocyte elastases from rodents In animal sepsis models sivelestat attenuates renal dysfunction reduces inflammatory markers like NGAL and increases survival rates Clinically this compound is utilized for managing acute lung injury associated with systemic inflammatory response syndrome and ARDS

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4,448

Medchemexpress LLC Targocil | 1200443-21-5 | 99.3% | 475.95 | 200 MG

Targocil is a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis. It is effective against both methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains, with MIC90s of 2 μg/mL for both. It shows excellent activity against S. aureus isolates from bacterial keratitis.

Bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis
Inhibits growth of methicillin-susceptible S. aureus (MSSA)
Inhibits growth of methicillin-resistant S. aureus (MRSA)
Effective against S. aureus strains Newman, MW2, MG2375, and MG2389
Low toxicity for HCECs at 5 μg/mL after 24 h exposure

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4,449

Medchemexpress LLC Corticosterone | 50-22-6 | 99.8% | 200 MG

Corticosterone is an orally active glucocorticoid produced by the adrenal cortex. It is involved in regulating neuronal functions within the limbic system, including the hippocampus, prefrontal cortex, and amygdala.

Enhances Rab-mediated AMPAR membrane traffic through SGK-induced phosphorylation of GDI.
Has an immunosuppressive effect by interfering with dendritic cell maturation.

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4,450

Apexbio Technology LLC Epalrestat 82159-09-9 200mg

Epalrestat (CAS 82159-09-9) is an orally available inhibitor of aldose reductase the rate-limiting enzyme of the polyol pathway involved in glucose metabolism By suppressing aldose reductase activity epalrestat limits intracellular sorbitol accumulation in neural tissues a process implicated in diabetic complications This compound is frequently employed in experimental models of diabetic neuropathy to investigate how modulation of the polyol pathway affects disease pathology and cellular signaling Epalrestat thus serves as a valuable molecular tool for elucidating the pathophysiology and pharmacology relevant to diabetes-associated neuronal damage

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4,451

Medchemexpress LLC 1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid | 368866-07-3 | MFCD02683117 | 99.4% | 466.53 | C26H30N2O6 | 1 ML

SARS-CoV-2-IN-86 is a research-grade small molecule inhibitor of SARS-CoV-2 methyltransferases (nsp14 and nsp16), provided for in vitro biochemical and antiviral studies. It is available as solid material and as a 10 mM solution in DMSO, with documented purity and storage recommendations to support reproducible experimental use.

High purity (99.35%) for reproducible results.
Available as 10 mM solution in DMSO or as solid for flexible assay workflows.
Well-characterized chemical identity (CAS 368866-07-3) and formula for traceability.
Suitable for biochemical methyltransferase and antiviral research applications.
Defined storage conditions to preserve stability in powder and solution formats.
Datasheet available with specification and handling information.

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4,452

Medchemexpress LLC GW 4064 | 278779-30-9 | 99.8% | 542.84 | 200 MG

GW 4064 is a potent Farnesoid X Receptor (FXR) agonist with an EC50 of 65 nM.

Reduces lipid accumulation in cells and represses oleic acid-induced CD36 protein levels, potentially preventing hepatic lipid accumulation.
Suppresses weight gain and significantly represses diet-induced hepatic steatosis by lowering triglyceride and free fatty acid levels in the liver.
Markedly reduces lipid transporter CD36 expression without affecting genes directly involved in lipogenesis.
Attenuates hepatic inflammation.
Leads to statistically significant reductions in serum activities of ALT, AST, LDH, and ALP, as well as reduced serum bile acid levels, suggesting hepatoprotective benefits.

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4,453

Medchemexpress LLC Beta-ionone | 14901-07-6 | MFCD00001549 | 99.9% | 192.30 g·mol⁻¹ | C13H20O | 200 MG

β-Ionone is a small aromatic ketone (C13H20O) used as a research reagent and analytical standard. It is a light yellow to colorless liquid and has reported activity inducing apoptosis in gastric adenocarcinoma SGC7901 cells.

CAS number: 14901-07-6
Molecular formula: C13H20O
Molecular weight: 192.30 g·mol⁻¹
Purity: ~99.9% (high purity for research)
Available pack sizes: 10 mM (1 mL in DMSO), 100 mg, 200 mg, 500 mg, 1 g
Typical applications: apoptosis research and analytical assays

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4,454

Apexbio Technology LLC Palifosfamide 31645-39-3 200mg

Palifosfamide (CAS 31645-39-3) is the active metabolite derivative of ifosfamide (IFA) an alkylating agent exhibiting cytotoxic effects through cross-linking DNA strands thereby interfering with replication and transcription Palifosfamide lysine demonstrates anticancer activity against pediatric sarcoma cell lines including osteosarcoma models such as SAOS-2 (IC50 2 25 6 75 M) and decreased sensitivity in OS222 (IC50 31 5 M) In murine xenograft experiments (MX-1 tumors) palifosfamide treatment at 100 mg/kg showed substantial tumor growth inhibition ( 80%) and partial complete response rates ( 17%) highlighting its applicability in preclinical oncology research

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4,455

Apexbio Technology LLC SR1078 1246525-60-9 200mg

SR1078 (CAS 1246525-60-9) is a small-molecule agonist targeting retinoic acid receptor-related orphan receptors alpha and gamma (ROR and ROR ) It is designed to selectively activate these nuclear receptors thereby regulating transcriptional processes involved in metabolic homeostasis and immune responses SR1078 exerts its biological activity primarily through direct binding to the ligand-binding domains of ROR and ROR promoting receptor-mediated transcription In in vitro studies treatment of HepG2 cells with SR1078 enhances ROR-driven gene expression including upregulation of glucose-6-phosphatase and fibroblast growth factor 21 mRNA levels Based on these pharmacological properties SR1078 holds research potential in studying ROR / -mediated biological pathways and their physiological functions

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Quinolines and derivatives

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Medchemexpress LLC N-(ethoxycarbonylmethyl)-6-methoxyquinolinium bromide | 162558-52-3 | 99.8% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Racemic equol | 94105-90-5 | MFCD00016662 | 99.6% | 242.27 g·mol⁻¹ | C15H14O3 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amg-337 | 1173699-31-4 | 99.4% | 463.46 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Infigratinib | 872511-34-7 | 99.8% | 560.48 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Targocil | 1200443-21-5 | 99.3% | 475.95 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Corticosterone | 50-22-6 | 99.8% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GW 4064 | 278779-30-9 | 99.8% | 542.84 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Beta-ionone | 14901-07-6 | MFCD00001549 | 99.9% | 192.30 g·mol⁻¹ | C13H20O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More